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Nat Rev Immunol (2016) 16:55365.10.1038/nri.2016.70 6 BuckMDSowellRTKaechSMPearceEL

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Similarly, TFEB-mediated autophagy played a crucial role in the protective effects of UA in BV2 cells by upregulating the expressions of Beclin-1, LAMP1, and the LC3II/I ratio, while the knockdown of TFEB by siRNA markedly decreased autophagy activity in A + UA-treated BV2 cells