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These enzymes regulate the redox homeostasis in the body by reducing lipid peroxides, allowing the body to recover from oxidative stress to a normal physiological state (McMahon et al., 2006

Evidently, the gut microbiota affects ferroptosis by regulating iron metabolism and related metabolites, and ferroptosis plays a crucial role in the progression of CKD

Shishir MRI, Xie L, Sun C et al (2018) Advances in micro and nano-encapsulation of bioactive compounds using biopolymer and lipid-based transporters

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Specifically, D139 (TM2) forms a hydrogen bond with Y482 (TM11) in the inward-facing structure, stabilising a straightened conformation of TM11 (Fig