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As shown in Supplementary Table 5 , all other liver-associated parameters (-GT, ALP, ALT, bilirubin) varied significantly over time, with an increase due to LPS administration and a subsequent decrease to baseline until the end of the experiment

These results identify ABCC1 and glutathione metabolism as mechanisms limiting efficacy of BCL-2 inhibitors, which may pave the way to development of more effective therapies

M., Macgibbon, K

Mechanism of action : Perampanel is a selective, non-competitive AMPA-type glutamate receptor antagonist

A proposed pathophysiological mechanism for the possible link between ketosis and PP is based on the passage of ketone bodies from the bloodstream into the perivascular space and induction of cytotoxicity and inflammation

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