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Hair and nail germ formation and elongation assay For the formation and elongation assay of hair and nail germs, primary skin dermal fibroblasts, skin epidermal keratinocytes, hair follicle dermal papilla cells, and nail fibroblasts (onychofibroblasts) were obtained from patients under ethical considerations

This has been experimentally demonstrated by silencing the estrogen receptor in breast cancer (ER+) with consequent decrease of OCTN2 expression (Wang et al., 2012)

5.1.5 Genetic alterations in the AKT gene AKT plays a central role in many signaling pathway, and its overexpression and phosphorylation-driven activation are common events in human cancers