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oestradiol (E2) bind ER or ER in mammary epithelial cells, followed by receptor dimerisation, nuclear translocation and direct transcriptional regulation of EREs in promoter regions on target genes that regulate cell proliferation cyclin D1, c-Myc -, survival Bcl-2 or survivin -, angiogenesis VEGF -, EMT Snail, Twist -, metastasis MMPs (185), as non-genomic oestrogen signalling via membrane-localized ER and G proteincoupled oestrogen receptor (GPER) leads to rapid stimulation of PI3K/Akt, MAPK/ERK and Src pathways interacting further impetus to mitogenic and anti-apoptotic effects

Another concern about the NRF2 activation is a lack of specificity

J Int Soc Sports Nutr 15, 30 (2018) doi:10.1186/s12970-018-0235-x Al-Amery, Akbal & Abdulshaheed, Ahmed & Al-Ebady, Saed & A.L

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Shumakovich, M

The effect of modulation of glutathione levels on markers for aflatoxin B1-induced cell damage