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In this study, we observed a slight decrease in the area of immunoreactivity for the presynaptic marker synaptophysin over time in cortical areas and the hippocampus in both groups, potentially reflecting spine ramification over time or differences in IGF-1 administration for the P5 (intra-arterial) and P9 (subcutaneous) end points, although treated pigs at both time points had IGF-1 plasma levels within physiological relevant levels

A separate investigation demonstrated that the RNA circKIF4A facilitates the malignant progression of PTC through its interaction with miR-1231, subsequently upregulating the expression of GPX4, an antioxidant protein (65)