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NNMT has been linked to a number of diseases/conditions

Each combination should be designed around individual goals, health status, and response to therapy

The number of clusters was determined using the sum of squared estimate of errors curve

This enzyme slows metabolism and contributes to fat accumulation

Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

It is possible that compensatory mechanisms could develop that reduce efficacy with prolonged use