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It was found that reduced expression of the D2R in the nucleus accumbens and hippocampus was correlated with greater seeking during signaled non-availability of the drug supporting the overall effect of neurotransmitter activity within the mesolimbic system, resulting in the reward, in which the NAc releases DA and then interacts with dopamine D1-D5 receptors [29]

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J Appl Physiol 120:11961206

In methionine choline-deficient diet-induced non-alcoholic steatohepatitis mice, esculin (20-40 mg/kg) also inhibits the NF-B signaling pathway, downregulates the expression of TNF- and IL-6, and increases the expression level of the silent information regulator 1(99)

Ni et al., 2019

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