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Anti-inflammatory and antioxidant actions also contribute to its synergistic anticancer effects by dampening STAT3-driven tumor-promoting feedback and inhibiting oncogenic pathways including mTOR, PI3K/Akt, and Wnt/-catenin (Li et al., 2018

doi: 10.1016/j.fsi.2019.12.054 61 DawoodM

500 ng of peptides loaded on Evotip pure devices (Evosep) according to manufacturer protocol were separated using the pre-programmed 60 samples per day gradient on an 8 cm length 100 m ID capillary column (Evosep)

SELENOP reduces tau aggregation by modulating tau protein phosphorylation and promotes the disaggregation of pre-formed tau tangles [111]

doi: 10.1007/s11523-023-00956-8

doi: 10.1038/s41386-024-02040-9 246 TureckiGMeaneyMJ