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Front Biosci S4(2):286 Lee JA, Son HJ, Park KD, Han SH, Shin N, Kim JH et al (2015) A novel compound ITC-3 activates the Nrf2 signaling and provides neuroprotection in Parkinsons disease models

Cell 187, 428445

Superoxide anions level was expressed as nanomoles of 2-hydroxyethidium (2-OHE), and the calibration curve was prepared using the extinction coefficient of 2-OHE ( = 9.4 mM 1 cm 1 )

In addition, iron acts as the active center of lipoxygenase, which oxidizes polyunsaturated fatty acids on cell membranes through an iron-ion-dependent chain reaction, thereby promoting the proliferation of phospholipid peroxides and thus causing ferroptosis

It is also studied for neuroprotective effects, promoting recovery from neurodegenerative conditions and possibly enhancing mental vitality and stress resilience