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Folinic acid can cross the blood-brain barrier using the reduced folate carrier (RFC) when the FR is blocked by FRAAs or non-functional due to mitochondrial dysfunction and/or genetic mutations

Higher CD34 expression was noted in non-cirrhotic vs cirrhotic PC regions (median: 2.27 vs 1.45, p =0.046) and higher VEGF expression was observed in middle-stage (IF 3-4) vs cirrhotic PC zones (95.77 vs 41.64, p =0.018)

For multi-arm or longitudinal studies, researchers can correlate batch-specific variation with endpoint variation, something that is awkward to reconcile when reconstituting from unlabelled lyophilised vials across multiple sessions, where each reconstitution introduces fresh variables

Anything less than 200 pg/ml is generally considered to be a deficiency

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