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This novel combination approach could serve as an alternative strategy for patients with limited treatment options due to poor performance status and those who are not viable candidates for traditional therapies

TRAP staining further revealed that JSH-23 treatment dose-dependently decreased the numbers of TRAP-positive osteoclasts and osteoclasts lining the bone surface (OC.S/BS) (Figures 8C,D)

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Insulin-like growth factor-1 (IGF-1) has long been implicated in prostate cancer (PCa) pathogenesis and progression, promoting tumor growth through activation of the IGF-1 receptor (IGF-1R)