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polynucleotide shuffling & interrupted synthesis non-stochastic polynucleotide reassembly which is described herein, can result in optimization of a desired property even in the absence of a detailed understanding of the mechanism by which the particular property is mediated

Sherman DS, Mauser J, Nuno M, Sherzai D

doi: 10.1016/j.rvsc.2013.01.024 5 YuJLuoSQXiangWJMengZXWangYRenJLet al

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Molecular mechanisms of insulin-like growth factor-I mediated regulation of the steroidogenic acute regulatory protein in mouse Leydig cells