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Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability

Wang HH, Liu M, Li X, Portincasa P, Wang DQ

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Adaptive Responses In the face of oxidant stress, hepatocytes adapt in an attempt to reduce oxidants and maintain oxidative phosphorylation and mitochondrial integrity

Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult

To validate the reporter, we treated JE2-lux and wild-type JE2 with 00.5 mM sodium arsenate, which induces ATP depletion 1 , and measured bioluminescence and ATP levels