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CDK5 phosphorylates ERK5 at T732, which not only activates its transcriptional activity but also allows ERK5 to act as a transcriptional coactivator for the AP-1 transcription factor

277 MTs expression is subject to dynamic regulation by both oxidative stress and cellular zinc levels

Moreover, the brains rich content of metal ions, such as iron, facilitates oxidative stress and DNA damage through the Haber-Weiss reaction (Suma et al., 2020), and promotes the aggregation of -synuclein, leading to the formation of Lewy bodiesa key pathological feature of PDD and Lewy body dementia (Wakabayashi et al., 2007)

Recent molecular and cellular studies show that when vascular endothelial cells or tissue stem/progenitor cells die, additional reactive pathways are set off, leading to even more significant cell loss, tissue damage, fibrosis, necrosis, and impairments in function [27]

ACS Chem Biol 15:469484

N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells