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492 These findings suggest that hyperglycemia is only one of multiple factors contributing to neuropathy in T2DM, highlighting the need for a multifactorial approach to management

The fat cell targeting mechanism remains active, but with less total adipose tissue available to mobilize, changes occur more gradually

Some of the common signs include: Persistent fatigue or weakness Pale or yellowish skin Numbness or tingling in hands and feet Memory issues or brain fog Shortness of breath or dizziness Sore tongue or mouth ulcers Skin pigmentation changes or vitiligo-like patches If youre experiencing any combination of these symptoms, especially along with skin discoloration, its essential to get tested for Vitamin B12 deficiency through a simple blood test

[13] [16] For patients taking GLP-1/GIP medicinesparticularly those on concurrent metformin, following restricted diets, or with pre-existing malabsorption conditions proactive monitoring and management of B12 status should be considered an integral component of comprehensive care

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However, these effects are usually temporary and can be managed with proper dosage adjustments