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Glutathione is often referred to as the master antioxidant because of its vital role in neutralizing free radicals, protecting cells from oxidative stress, and supporting the bodys natural detoxification processes

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Other mechanisms that sustain AR action under ADT include expression of AR from ecDNAs or induction of the structurally related nuclear receptor glucocorticoid receptor (GR) that can take over control over at least a fraction of the AR-dependent cistrome and transcriptome [37,38,39]

Furthermore, previous bioinformatics analysis has uncovered a significant association between elevated MMP-14 expression and several angiogenesis-related signaling pathways, such as Visfatin, VEGF and TGF-, as well as the endothelial-mesenchymal transition process (55)