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The downstream analysis was performed using R (version 4.1.0) with the MSstatTMT package (version 2.0.1) 103

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This small molecule, with its unique molecular structure, has been linked to potential interactions with amino acids and as a potent activator of sirtuins, a class of proteins involved in regulating cellular health and longevity, suggesting a nuanced role in cellular processes that may further contribute to the compounds anti-aging properties

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

7.2 Stem Cells & Longevity NNMT expression maintains stemlike identity in embryonic stem cells , partly via its effect on methylation and metabolic state

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