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biloba treatment, inhibits the expression of TLR4, NF-B, iNOS, IL-1, and TNF-, and up-regulating the expression of Arg-1, and neurotrophic factors, significantly regulated the microglia and astrocytes dynamic balance, induced the oligodendrocyte precursor cells (OPCs) generation and promoted myelin production

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In MC4R, the mutant I291A cannot induce cAMP signaling, while substitution of I291 by the larger hydrophobic phenylalanine side chain partially retained signaling (Supplementary information, Fig

It has been reported that PD pathogenesis is significantly influenced by impaired mitochondrial activity and the ensuing rise in oxidative stress, neuroinflammation, and microglial activation (Moon and Paek, 2015)

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