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the dual GLP-1 receptor/glucagon receptor agonist, the dual GLP-1 receptor/GIP receptor agonist or the triple GLP-1 receptor/GIP receptor/glucagon receptor agonist may each be a conjugate (particularly a protein or peptide) comprising any of the GLP-1 receptor agonists described herein covalently attached, optionally via a linker, to a glucagon receptor agonist and/or to a GIP receptor agonist

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Animal studies suggest relatively rapid distribution following injection, with activity observed at both local and systemic sites