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Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)

DOI: 10.1002/adbi.20230025 Feature image credit: Kenny Eliason on Unsplash

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Cells involved in repair (fibroblasts, endothelial cells, muscle cells) appear to respond through signaling changes that support migration, collagen organization, and local tissue rebuilding