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The promotion of pulmonary inflammation, macrophage activation, and acute lung injury is potentially linked to the upregulation of pro-inflammatory cytokines (IL-1, TNF-) and overexpression of iNOS and Cox-2 immune markers 61,62,63

In the future, the biological mechanism of the antidepressant effects of Bifidobacterium still needs to be further clarified

The identified S- mycothiolated proteins function in many metabolic pathways, such as the central carbon metabolism, the biosynthesis of amino acids, nucleotides, thiamine and myo-inositol-1-phosphate as well in protein translation

Quercetin, a naturally occurring polyphenol, acts as a powerful immunomodulator and antioxidant

Therefore, it is possible that NPY modulation might be of benefit in some people with COPD, such as those that have pulmonary hypertension [130]

Aubert, J