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The key findings were: Tirzepatide met the primary goal of cardiovascular non-inferiority , confirming it is at least as safe for the heart as dulaglutide It did not quite meet statistical superiority over dulaglutide for MACE, although results trended in favour of tirzepatide Tirzepatide produced significantly greater reductions in HbA1c and body weight than dulaglutide Importantly, because SURPASS-CVOT used an active comparator with established cardiovascular benefit rather than a placebo, demonstrating superiority was inherently more difficult than in earlier placebo-controlled GLP-1 outcome trials

This advanced treatment combines microneedling with radiofrequency energy to stimulate collagen production, tighten skin, and reduce the appearance of fine lines, wrinkles, and acne scars for smoother, more youthful-looking skin

Why the topic of fasting is being revisited [1:45]

Advances in host-microbe metabolic axis

Interestingly, however, when powdered cuprizone was compared to pelleted control, the density of Olig2+ cells decreased in the caudal (p 0.05

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