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219 Severe homozygous loss-of-function mutations in ZIP8 lead to a type-II congenital disorder of glycosylation, increasing the risk of schizophrenia

confirmed that TFAP2C regulated GPx1 expression by directly binding to the GPx1 promoter, which contains an AP-2 regulatory region, and the methylation of the CpG island in the GPx1 promoter region prevented the binding of TFAP2C by encompassing the AP-2 regulatory region [81]

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Related impurities rendered during the manufacturing process (such as amidoamine and dimethylaminopropylamine) are thought to play a role in sensitization

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doi: 10.1021/acscentsci.7b00028 209 MishimaEItoJWuZNakamuraTWahidaADollSet al