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directed their research effort to restoration of functional recto-anal inhibitory reflex connections and defecation subsequent to resection and anastomosis in a guinea pig model

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Poly (ADP-ribose) polymerase-1 (PARP-1), a nuclear protein that plays a crucial role in DNA repair, genomic stability, and transcription is the key molecule in the parthanatos mechanism (112, 113)

Metabolism also plays a critical role in altering immune cell responses, thus exacerbating cancer progression (134, 142)

Washington, D.C.: ASM Press