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Selective protein arylation and acetaminophen-induced hepatotoxicity

The equilibration that results leads to a collapse of the proton-motive force across the membrane and a colloid osmotic pressure that causes massive swelling of the mitochondria (McStay et al., 2002)

Also, G127X patients had aggregates in glial cell nuclei of spinal cords, some of which were stained with an antibody (Chi 131153 ab) raised against a peptide sequence absent in G127X-mutant SOD1 (Asn131 - Gln153) [46]

This process takes place primarily in the mitochondrial cristae, and when electrons leak from the ETC, they react with oxygen to form superoxide anions, a key source of mitochondrial ROS (34)

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