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The crucial role of Janus kinases (JAK) in the pathogenesis of the disease has led to a change in the therapeutic landscape, opening new approaches in the management of this disease

J., Islam, M

Elfsmark L, Ekstrand-Hammarstrm B, Forsgren N, Lejon C, Hgglund L, Wingfors H

doi:10.1126/science.3260686

Elevated serum VEGF levels were observed in obese patients and this elevation has associations with visceral fat index and BMI (297, 300, 325)

Beyond specific pain syndromes, ozone therapy exhibits broader mechanisms, such as oxygenation, immune modulation, and anti-inflammatory action, and has been applied to other chronic conditions like ME/CFS and CFS [17, 67,68,69]