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Cell death initiation and cell cycle arrest at the G1/S boundary subsequently occur 41,42

Obviously, a growing body of preclinical evidences suggests that the induction of lipid peroxidation by inhibiting system x c - might be an effective therapeutic strategy to clear cancer cells and prevent the acquired resistance to several cancer drugs, such as lapatinib, dabrafenib and vemurafenib (Table S1) [228, 261, 262]

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12.15] for de novo cancer (p=0.05)