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Because TB-500 distributes systemically regardless of injection site, there is no requirement to inject near the injury

Lancet 2023 Phase 2 (T2D) Frias et al., n=92, 32 weeks

GLP-1R is concentrated in POMC/CART neurons of the arcuate nucleus, while GIPR is expressed on different neuronal subsets

The results have been consistent across dozens of high-quality rat studies that researchers got very excited

For research programs addressing primary MET alterations or investigating c-MET-driven EGFR-TKI resistance, the success of lead discovery depends heavily on the structural integrity of the target antigen