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To assess the potential role of PVN Glu neurons in modulating morphine-induced constipation, we directly infused morphine into the bilateral PVN through implanted cannulas (Fig

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Ethics declarations Competing interests The authors declare no conflict of interest

Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)

World J Gastrointest Pharmacol Ther 2020

This approach would allow for precise regulation of HO-1, inhibiting its harmful effects while preserving its antioxidative function