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38,238,243 Besides, the oscillation activation of SIRT1 also regulates the circadian dynamics via deacetylation of the core clock repressor PER2 K680 and mixed-lineage leukemia 1 (MLL1), thereby controlling rhythmic chromatin property and the activity of BMAL1: CLOCK complex

Finally, BPC 157 markedly improves the healing of traumatic nerve (18) and traumatic brain injury (19) and ameliorates encephalopathies that occur in severely intoxicated animals (20-23) and therefore, exhibits particular neuroprotective ability