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594 The OPTION-DM study determined which monotherapy and combination therapy of amitriptyline, duloxetine, and pregabalin are the most clinically efficacious

Among these, IL-4 and IL-13 have been identified as central pathogenic mediators that induce inflammation, impair skin barrier integrity, and provoke pruritus (Sehra et al., 2010

doi: 10.1002/art.41748 135 HitchonCWongKMaGReedJLyttleDEl-GabalawyH

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GHK-Cu helps balance MMP activity, promoting beneficial remodeling while preventing excessive tissue degradation that contributes to aging and poor wound healing

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