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Since H3K18la affects DNA transcriptional activity by enriching at the promoters of target genes, such as the oncogene c-Myc (20), this lactylation modification consequently confers therapy resistance by activating survival-related genes, including glutamate-cysteine ligase catalytic subunit (52)

In this issue of Plant Physiology , Speiser et al

Beyond its immune-boosting benefits, glutathione also regulates melanin production the pigment responsible for skin tone

Similar favorable results have also been reported in muscular dystrophy mice models, where sulforaphane treatment alleviated muscle inflammation in dystrophin-deficient mdx mice (Sun et al., 2015b)