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That is the reason it is considered relatively safe even at high doses

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Splitting doses also dilutes the fasted-state metabolic advantage the evening dose occurs during fed state when insulin is elevated, reducing fat oxidation efficiency

1,2 This restriction is based on animal studies where semaglutide and tirzepatide caused thyroid C-cell tumours in rats

Generative AI statement The author(s) declared that generative AI was not used in the creation of this manuscript

5-Amino-1MQ is a small molecule that blocks NNMT, an enzyme tied to fat storage