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This regulatory network is mainly manifested by abnormal hypermethylation of CpG islands in the promoter region, leading to transcriptional silencing of important tumor suppressor genes such as PTEN, RASSF1A, p16 (CDKN2A), and hMLH1

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Curcumin-decorated liposomes with mean vesicle sizes of 131207 nm were synthesized and evaluated for their integrity, stability and binding affinity to A 142 fibrils [259]