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In another study, PCA administration significantly prevented colitis symptoms, reduced pro-inflammatory cytokines and liver toxicity markers, and protected against oxidative damage in both the colon and liver, highlighting its chemoprotective role [360]

18 , 19 , 20 Furthermore, a high expression of STAT3 alters the cell cycle 21 , 22 and inhibits the apoptosis by upregulating anti-apoptotic signaling 23 , 24 in inflammation-associated CRC and other human cancers

In summary, this study demonstrates that calcium overload plays a critical role in the cytotoxicity associated with a-synucleinopathy, leading to mitochondrial damage, lysosomal dysfunction, and cell death

One mechanism that contributes to cytochrome c detachment from IMM involves cardiolipin oxidation because oxidized cardiolipin has a much lower affinity for cytochrome c than the reduced form

10.1105/tpc.12.10.1939 35 MontezanoA

10.1016/j.jneuroim.2005.09.012 34 NakajimaK.TohyamaY.MaedaS.KohsakaS.KuriharaT