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Interventions such as the antioxidant NAC or the inhibition of MAPK8/JNK activity have been demonstrated to mitigate ROS-induced parthanatos in glioma cells [156], suggesting that MAPK8 activation contributes to parthanatos by enhancing intracellular ROS levels

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It means we do not yet know whether it does

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These are categorically different for systemic endpoints like tendon healing or GH pulse stimulation