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This lipid A displays a unique structural feature, with a non-phosphorylated skeleton made up of the tetrasaccharide Man--(14)-GlcN3N--16-GlcN3N--(11)--GalA, and four primary amide-linked 14:0(3-OH) and, as secondary O-acyl substituents, a 16:0 and the very long-chain fatty acid 26:0(25-OAc), appended on the GlcN3N units

2 10 That oxidative stress, through the process of lipid peroxidation and resulting products of oxidative damage, may be implicated in the pathogenesis of SLE is evidenced by (1) an enhanced urinary excretion of isoprostanes, a well-established index of lipid peroxidation, in patients with SLE