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Variation across 141,456 human exomes and genomes reveals the spectrum of loss-of-function intolerance across human protein-coding genes

We show that PSR-1 forms condensates on the membrane at the tip of the growing axon in response to axon injury

To further clarify whether this metabolic regulation is mediated through the downstream AKT pathway, we introduced a constitutively active form of AKT (myr-AKT) into MAT2A-depleted OS cells

The cells were treated with 10 mM EtGSH in FluoroBrite DMEM for 34 h, 1 mM BSO in FluoroBrite DMEM for 34 h, 1 mM H 2 O 2 for 20 min in FluoroBrite or vehicle (FluoroBrite DMEM)