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10.1016/j.nicl.2016.03.017 NeuroImage Clin

Oral bacterial species and their products can affect the brain either directly through neural pathways such as the trigeminal, olfactory, and facial nerves, as well as via the circulating bloodstream, or indirectly through disturbances in the gut microbiota that promote systemic inflammation and neuroinflammatory responses ( Figure 10 )