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Description

Raele, D

Inflammatory cytokines such as TNF- and IL-1 also compromise mitochondrial biogenesis and fusionfission dynamics, interfering with cellular resilience and adaptation

So that is scenario one

pmid:21558000 15

For decades, researchers noticed it had two seemingly distinct functions: promoting growth (via IGF-1) and promoting fat breakdown (lipolysis)

Secondly, ketone bodies are metabolized in mitochondria, resulting in less NAD + consumption and an increase in the NAD + /NADH ratio in the cytoplasm (144)