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Continued opioid use despite having persistent or recurrent social or interpersonal problems caused or exacerbated by the effects of opioids

9 GSH deficiency could also arise from metabolic problems

The mTORC1 complex, which includes the regulatory associated protein of MTOR (RPTOR) protein, corresponds to the invertebrate TOR complex in its regulatory interactions, while mTORC2 controls other intracellular processes

J Biochem 146: 599608 DooleyCT,DoreTM,HansonGT,JacksonWC,RemingtonSJ,TsienRY (2004) Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators