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Description

A lossoffunction library will be used to find genes whose knockout reactivates MHCII, while a CRISPRa library will pinpoint activators capable of restoring antigen presentation

The mice recapitulate human NASH transcriptome and metabolome profiles and reveal a translational histopathology in the liver with steatosis, inflammatory aggregates and bridging fibrosis, as well as atherosclerosis development