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Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)

Furthermore, shikonin significantly downregulated the protein expression of toll-like receptor 4 (TLR4) and phosphorylated nuclear factor-kappa B (NF-B)

Intriguingly, recent research has shown that lactate is not only essential for efferocytosis but also for sustaining efferocytosis-induced macrophage proliferation, a process responsible for increasing the number of macrophages capable of performing continuous efferocytosis, thus contributing to the resolution of inflammation and tissue repair [87] (Fig

Focal, multifocal, and subcapsular necrosis is occasionally seen in untreated rodents and may be a terminal event potentially due to hypoxic change secondary to impaired blood flow

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