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Abstract While MRI contrast agents such as those based on Gadolinium are needed for high-resolution mapping of brain metabolism, these contrast agents require intravenous administration, and there are rising concerns over their safety and invasiveness

Furthermore, ultrasound scanning is operator-dependent

After this time, potential positive health benefits were observed in conditions such as rheumatoid arthritis and heart disease, as well as adverse effects 49

Additionally, research conducted in Spain indicated that the ApoE4 allele is more prevalent in familial PD but less common in sporadic PD compared to control groups, suggesting a potential risk association in individuals with specific genetic backgrounds (Blzquez et al., 2006)