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Epidemiological studies conducted on patients suffering from migraine, inflammatory bowel disease, and asthma showed an increased risk of developing the so-called complex regional pain syndrome (CRPS) in the limbs owing to the destruction of nerve fibers [54]

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Deciphering the reversible glutaredoxin-dependent redox reactions of roGFP2 therefore not only closes a gap in our knowledge of glutaredoxin catalysis but also facilitates the intrepretation of roGFP2 responses from redox measurements and mechanistic analyses in vivo

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