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Journal of the Chinese Medical Association

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Superoxide anion (O 2 ) is an important ROS and is formed by several enzymatic and non-enzymatic pathways (Figure 2)

These enzymes were selected for further investigation, using UV-visible spectrophotometric enzyme activity assays, on the basis of their importance in mediating acetyl-CoA synthesis and transport into the mitochondria

4 Challenges and perspectives of ferroptosis in kidney diseases Ferroptosis, an iron-dependent regulated cell death driven by lipid peroxidation, has emerged as a central pathogenic mediator in kidney diseasesan organ uniquely susceptible to redox imbalance due to its high metabolic activity, abundant iron handling, and structural heterogeneity (276, 277)

This triad governs the transition from glycolytic crisis to lipid storm, presenting druggable nodes for time-sensitive interventions