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Anakinra is an IL-1 receptor antagonist used for treating moderate-to-severe RA that has been unresponsive to initial disease-modifying anti-rheumatic drug (DMARD) therapy

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A gene-level shRNA score below 0 indicates reduced cell viability, equal to 0 indicates no effect on viability, and above 0 indicates enhanced viability

In response to oxidative stress, p62 activates NRF2 by directly binding to its ubiquitin ligase adapter KEAP1

Ach donated by adjacent FRCs promoted lipid influx into B cells through CD36, facilitating FAO and subsequent generation of autoreactive cells (110)

Conclusion In sum, perturbation of Met metabolism may promote the damage process of hepatobiliary injury triggered by viral infections/toxins and/or niche abnormalities, with dysregulated inflammatory and immune responses of the liver, and contribute to the obliteration and eventual fibrosis and atresia of the bile ducts in the initiation/progression of BA