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When the acetyl-CoA generated from the beta-oxidation of fats enters the Krebs cycle, it undergoes a series of transformations, eventually reaching the stage where succinate is converted into fumarate by the enzyme succinate dehydrogenase

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employed HILIC coupled with tandem mass spectrometry (HILIC-MS/MS) to determine carnitine and eleven acylcarnitines in human serum and rat tissue biopsies (Kivilompolo et al., 2013)

There is an urgent need for larger studies to determine the role of vitamin B12 supplementation alone, or in combination with other therapeutic agents, in prevention or reversal of MS, and aid in improved quality of life of MS patients