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Notably, phosphorothioates and dithioates are often pro-toxicants, requiring oxidative desulfuration by hepatic cytochrome P450 enzymes to convert into active oxon forms (e.g., parathion paraoxon), which are potent acetylcholinesterase inhibitors

Dany M, Gencer S, Nganga R, Thomas RJ, Oleinik N, Baron KD, et al

Synthesis of 3-keto-4-diazo-5--dihydrosteroids as potential irreversible inhibitors of steroid 5--reductase.Tetra.Lett.1980,21, 15-18 75

TBI induced the change of gut microbiota components, including a decrease of Anaerotruncus , Firmicutes-unclassified, Lachnospiraceae-unclassified , and Ruminococcus-1 and increase of Muribaculum and Gastranaerophilales-unclassified ( Figure 4B )